Age-Related Decrease in Striatal DA Produces Cognitive Deficits in Male Rats

Aging is a process that presents various alterations in physiological, behavioral and neurochemical processes. It causes impairment of CNS functions which lead to changes memory, cognition other performances. Reports have shown aging physiological functions. The aim the present study was evaluate cognitive relation aging. For this 20 male rats were taken, 10 young (4-6 months) old (18-22 months). Morris Water Maze (MWM) test performed monitor learning memory while Object-Recognition Task (ORT) function. After assessment decapitation done rat brain dissected isolate striatum. Then analysis by HPLC-EC striatal DA DOPAC levels. Results tests showed aged exhibited significant long-term memory. While ability assessed ORT also impaired rats. Neurochemical results there decline dopamine (DA) concentration its metabolite significantly increased Hence has negative influence on Age-related deficits may occur as result levels striatum leading performance.